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New research from King’s College London asks one of the most pressing questions in mental health science: why does cannabis use raise the risk of psychosis in some people but not others? Scientists published the findings in Biological Psychiatry: Global Open Science in 2026. They point to a complex web of shared genes and biological pathways that may one day help identify the most vulnerable individuals early.
For anyone who has seen a young person’s mental health deteriorate alongside heavy cannabis use, this research feels significant. It moves the conversation beyond statistics and into biology, offering a clearer picture of what actually happens at the molecular level.
What the Genetics Reveal About Cannabis Use and Psychosis Risk
The team at the Institute of Psychiatry, Psychology and Neuroscience (IoPPN) conducted a large scale genetic analysis drawing on data from over 547,000 participants. Rather than study schizophrenia alone, they built a broader “combined psychosis” group that also included bipolar I disorder. This better reflects how cannabis related psychosis presents in real life.
Their analysis uncovered more than 550 genetic locations linked to psychosis, including 122 entirely new associations. They also found that far more biological pathways overlap between cannabis use disorder and psychosis than chance alone would predict. This strongly suggests the two conditions share genuine biological roots, not simply co-occurring for social or lifestyle reasons.
Using a method called Mendelian randomisation, researchers confirmed that cannabis use disorder causally raises the risk of psychosis. That causal effect ran stronger from cannabis use to psychosis than in the reverse direction.
Three Distinct Routes from Cannabis Use Disorder to Psychosis
At least three separate genetic clusters drive the link from cannabis use disorder to psychosis. Each cluster points to a different biological mechanism, which helps explain why the relationship looks so varied in clinical settings.
The first and third clusters involve genes tied to synaptic signalling and neuronal development. Cannabis may disrupt how nerve cells connect and communicate, especially during critical windows of brain development in adolescence and early adulthood.
The second cluster carries the strongest genetic signals. It connects to intracellular signalling, epigenetic regulation, and gene expression. In plain terms, heavy cannabis use may alter how genes switch on or off. Those changes could contribute to the onset of psychotic illness.
Only one causal cluster ran in the opposite direction, from psychosis to cannabis use. This suggests less biological variation in why people with psychosis might turn to cannabis, which mirrors what clinicians tend to observe.
The Glutamate Connection and Cannabis Use and Psychosis Risk
One system appeared consistently across every analysis: the glutamate pathway. Glutamate is the brain’s primary excitatory neurotransmitter, and scientists have long linked disruption in this system to psychosis.
Genetic scores built around glutamate related genes were the strongest predictors of psychosis across the entire sample. Those scores remained predictive both in cannabis users and in people who had never used the drug, though the effect was particularly strong among users.
THC, the psychoactive compound in cannabis, acts on CB1 receptors that sit on glutamatergic neurons. The research team suggests cannabis may amplify an existing underlying vulnerability in this system, potentially tipping susceptible individuals towards psychosis.
Professor Marta Di Forti, the study’s senior author, put it plainly: genes involved in the glutamate system might one day help identify those at greater risk of developing psychosis when using cannabis.
Why Cannabis Use and Psychosis Risk Research Matters Now
Cannabis sits among the most widely used substances in the world. Debates about legalisation continue across many countries, and that makes understanding who carries the greatest risk far more than an academic exercise.
Among cannabis users, genetic vulnerabilities in neuronal pathways, covering axon development, dendritic structure, and synaptic function, all associated with higher psychosis risk. This raises a real prospect: developing tools that flag high risk individuals before psychosis takes hold.
Biological pathways tied to GABAergic signalling and calcium channel activity lost significance once researchers statistically removed cannabis use from the equation. Those pathways may therefore be specific to cannabis related psychosis rather than psychosis in general. That distinction could eventually point towards more targeted clinical approaches.
What This Research Means Going Forward
This study adds weight to a growing body of evidence. The link between cannabis use and psychosis risk is not simply a lifestyle or environmental story. Genetics play a real part, and the biological picture is becoming clearer.
The study carries important caveats. Researchers drew data almost entirely from people of European ancestry, which limits how widely the findings apply globally. The pathway based genetic scores are exploratory and need replication in larger samples before anyone could use them in practice.
Still, the direction is clear. Science around cannabis use disorder and psychosis is becoming more precise. The hope is that greater precision will eventually translate into better identification of those most at risk and more targeted support for those already affected. (Source: WRD News)
Also See:
- All Young Cannabis Users Face Psychosis Risk
- Cannabis & Psychosis – Irrefutable
- C.I.P – Cannabis Induced Psychosis
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Cannabis is the most commonly used illicit substance during pregnancy. Many pregnant people are unsure of the risks or where to turn for support. Researchers are exploring practical, accessible ways to help expectant mothers reduce or stop use. One of the most promising approaches may be as straightforward as putting on a pair of trainers.
A recent study by Cynthia L. Battle and colleagues examined a structured walking programme for pregnant individuals. The goal was to see whether it could help them cut back on cannabis use during pregnancy whilst also supporting their mental wellbeing. The findings are encouraging.
Walking to Reduce Prenatal Cannabis Use: What the Study Found
Researchers recruited 16 pregnant adults between 12 and 25 weeks gestation. They came from OB-GYN clinics in Rhode Island and through online channels. All participants used cannabis at least weekly before pregnancy. They also wanted to reduce or stop use and reported symptoms of depression or anxiety.
Over ten weeks, participants took part in a structured walking programme. Clinicians led six sessions in total, each building on daily step goals from the previous week. Participants also wore Fitbit devices to track their steps throughout.
The numbers tell a clear story. At the start, 62.5% of participants were still using cannabis. By 36 weeks gestation, that figure fell to just 16.6%. Symptoms of depression and anxiety also dropped over the course of the programme and stayed lower at the one month postpartum mark. Attendance was strong too. 88% of participants completed the programme, attending an average of 5.8 out of 6 sessions.
Why Physical Activity Matters for Cannabis Use During Pregnancy
Regular, moderate physical activity is already part of the guidance for a healthy pregnancy. Exercise also has well-established benefits for mood and stress. Both of these matter for pregnant people who may be using cannabis to cope with anxiety or low mood.
Understanding why someone uses cannabis during pregnancy is just as important as encouraging them to stop. For some people, it manages symptoms that feel otherwise unmanageable. A walking programme offers an alternative outlet for stress and anxiety. It addresses the behaviour alongside the underlying need.
Healthcare providers play a key role here. When they understand why a patient may be using cannabis, they can help that person find constructive ways to cope. Physical activity is one such option, and this research shows pregnant people are genuinely willing to engage with it.
Prenatal Cannabis Use Does Not Always Stop After Birth
One finding from this study stands out. Whilst cannabis use during pregnancy dropped significantly, it rose again to 50% at one month postpartum. That is a striking reversal, and it points to something important: support cannot simply end at birth.
The postnatal period brings its own pressures. Without continued guidance, the progress made during pregnancy is hard to maintain. Longer term conversations between providers and patients are essential. Continued awareness of the risks matters too, both for the parent and for the child.
What This Research Means Going Forward
This was a small, preliminary study without a control group. It cannot definitively prove the walking programme caused the reduction in prenatal cannabis use. Participants already wanted to change, which may also have shaped the results. Larger, more rigorous trials are the next step.
Even so, the study makes a useful case. A walking programme costs little, requires no specialist equipment, and carries no known risks during a healthy pregnancy. It also improved mood and reduced anxiety alongside cannabis use. That combination is worth taking seriously.
The conversation around cannabis use during pregnancy needs to be honest and grounded in real support. Research like this moves that conversation forward in a practical direction.
(Source: WRD News)
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Back in 2020, the National Drug Research Institute at Curtin University finally got around to tallying up what cannabis costs in Australia were actually doing to the country. The last time anyone had done this properly was 2007 — thirteen years earlier. The number they landed on for 2015–16? $4.5 billion. In a single year.
It barely made a ripple. And since then? Nobody in authority has bothered to update it.
That’s not an oversight. That’s a choice.
What Did $4.5 Billion Actually Buy Us?
In the 2015–16 financial year, more than 2 million Australians used cannabis. Around 150,000 were clinically dependent on it. And 3,422 adults were serving prison sentences directly attributable to cannabis.
The bill broke down like this:
- $2.4 billion — Crime. Policing ($475M), imprisonment ($1.1 billion), courts, legal aid, crime victims. More than half the total, right there.
- $714 million — Healthcare. Mental health programmes, hospital admissions, psychosis presentations.
- $560 million — Workplace. Absenteeism and lost productivity.
- $470 million — Other social costs, including child protection.
- $194 million — Road trauma.
- $106 million — The intangible cost of 23 people who didn’t come home. Over 850 years of life, gone.
Total: $4.5 billion.
Anyone still want to argue that cannabis is a harmless personal choice with no impact on anyone else? The numbers say otherwise and these are the conservative numbers from nearly a decade ago.
The Counting Stopped. Funny That.
The NDRI had been working through a series of national cost reports — methamphetamine, tobacco, opioids, then cannabis. Solid, rigorous work.
Then it stopped.
In the years since 2016, Australia’s cannabis policy environment shifted dramatically. Decriminalisation pushes. Legalisation campaigns dressed up as social justice. And most significantly — the rapid expansion of dodgy ‘medicinal’ cannabis prescriptions.
It is hard not to notice that the national cost-accounting exercise was quietly wound down at precisely the moment it became politically inconvenient. When the evidence doesn’t fit the narrative, apparently the solution is to stop producing the evidence.
The communities, families, healthcare workers and kids left dealing with the real-world fallout deserve better than that.
‘Medicinal’ Cannabis: Pull the Other One
Here are the actual numbers, because they need to be seen to be believed.
In 2017 there were 231 medicinal cannabis prescriptions in Australia. By January 2024, over one million Australians were using medicinal cannabis products — confirmed by the Australian Health Practitioner Regulation Agency. More than 2.7 million prescriptions have been issued since legalisation, according to TGA data.
Let’s call that what it is: a regulatory loophole that has done more to normalise cannabis use across the broader population than any legalisation campaign could have achieved directly. And — worth noting — there is very little evidence it is even effective for anxiety or chronic pain, which are among the most common conditions it is now prescribed for.
And here’s the thing: the harms don’t care what it says on the packet. The link between cannabis and psychosis was already flagged as clinically significant in the 2015–16 NDRI data — cannabis-related psychosis presentations were the most costly cannabis-related hospital admissions in the country. Nothing since suggests that has improved.
The ‘medicinal’ label does not make the social costs disappear. It just makes them easier to ignore — and harder to count, because we’ve stopped counting.
That $4.5 Billion? Just the Opening Act
The $4.5 billion figure reflects 2015–16. Here’s what has changed since:
The user population has grown. The Australian Institute of Health and Welfare recorded 2.5 million Australians using cannabis in the 12 months to 2022–23 — up from 2 million in the period the NDRI examined. Daily use among recent users has jumped from 14% in 2019 to 18% in 2022–23.
The prescription numbers have exploded — from 231 in 2017 to over one million patients by January 2024.
And the original $4.5 billion was already an undercount. The researchers themselves flagged that the cost of presenteeism — workers turning up impaired — hadn’t been adequately measured and needed further research. Nearly a decade later, that research still hasn’t been done.
Factor in a decade of cost inflation across health, justice, and social services — and that 2015–16 figure looks increasingly like a floor, not a ceiling.
Kids, Families, Communities: That Is Who Is Paying
Behind every dollar of that $4.5 billion is a person. A family. A young person whose developing brain was exposed to a drug that carries real, documented risks — risks that have been systematically downplayed as the normalisation machine has rolled forward.
The child protection cost alone — $470 million — doesn’t exist in a vacuum. It represents kids removed from homes, families fractured, caseworkers overwhelmed. The mental health burden lands on communities that were never resourced to carry it. The road trauma touches families who never saw it coming.
This is not abstract. It is happening in suburbs and country towns across Australia, quietly, expensively, and with no updated national reckoning to show for it.
So Where Does That Leave Us?
Cannabis costs in Australia were $4.5 billion in 2015–16. The user population has since grown to 2.5 million. Daily use is up. Medicinal prescriptions have gone from 231 to over a million. And the national cost-accounting has not been updated once.
That number has not gone down. It has gone up — and nobody in authority is measuring it.
The only honest response is to demand the evidence be updated, the true costs be counted, and policy be built around protecting communities rather than accommodating an industry that profits from permission.
The families, schools, and young people carrying the real costs of this drug already know the answer. It’s time the data caught up.
(Source: WRD News)
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More pets are turning up at veterinary emergency rooms in serious distress. The cause, increasingly, is cannabis poisoning in pets. Experts say the numbers are climbing fast and show no sign of slowing down. As more countries and US states legalise cannabis, the risk to household animals keeps growing, yet too many owners still have no idea it exists.
The Animal Poison Control Centre recorded a 300% rise in calls about marijuana toxicity in dogs and other pets between 2018 and 2023. That figure captures something important: wider drug availability brings consequences that go well beyond the humans using it.
Why Dogs Face a Higher Risk of Cannabis Poisoning
Dogs do not process tetrahydrocannabinol (THC) the way humans do. Their bodies react to it far more severely, and at far lower doses. Dr Ashton Townsley, lead emergency veterinarian at Veterinary Emergency Group (VEG) in Torrance, California, puts it plainly.
“Even just a normal ingestion for what a human might take becomes a toxicity in dogs,” he said.
There is no safe threshold owners can rely on. A half-smoked joint left in the garden, an edible sitting on a coffee table, something sniffed up on a walk: any of these can send a dog into a frightening medical spiral. Owners often do not know it has happened until the symptoms are already showing.
How to Spot Marijuana Toxicity in Dogs
Dr Townsley says he can often pick out cannabis poisoning in pets from across the waiting room. The signs cluster together in a way that is hard to miss.
Watch for a lurching, unsteady gait, similar to a drunken walk. Look for dilated pupils, sharp over-reactivity to normal sounds or movements, and loss of bladder control. When those signs appear together, experienced vets treat it as highly suspicious straight away.
Diagnosis is not always straightforward. Urine tests on dogs can return false negatives. Many owners also hold back information. “It is the rare pet parent that comes in knowing their pet got into marijuana, or is willing to admit it,” said Dr Townsley. He often has to draw the history out carefully, reminding owners that a neighbour’s discarded pre-roll or something picked up on a walk could easily be the cause.
A 2022 survey of small animal vets across North America found that over 60% had treated at least one case of cannabis ingestion in the previous year, with most reporting an increase compared to five years prior. The problem is spreading quietly through waiting rooms everywhere.
How Long Does Cannabis Poisoning in Pets Last?
Milder cases of marijuana toxicity in dogs usually clear within 8 to 12 hours. More severe exposures keep animals unwell for up to 48 hours. Fatalities are uncommon, but Dr Townsley has treated cannabis-related comas, tremors and seizures. These are not outcomes to brush off. “At higher doses, there are some severe side effects,” he said.
The Double Danger of Edibles
Cannabis poisoning in pets becomes significantly more dangerous when edibles enter the picture. Chocolate edibles add their own layer of toxicity for dogs. Gummy sweets are often worse: most contain xylitol, an artificial sweetener that causes serious harm to dogs even in tiny amounts.
“We have to act very aggressively, more for the xylitol toxicity than for the marijuana ingestion itself,” said Dr Townsley.
A dog that eats a cannabis gummy is not fighting one problem. It is fighting two at the same time. Treatment becomes more complex, more urgent and harder on the animal. This is the scenario vets dread most.
What to Do If You Suspect Your Pet Has Been Exposed
Act quickly. If your pet shows signs of marijuana toxicity, get to a vet without delay. Do not wait to see if things settle. Tell the vet everything you know or suspect about what your animal consumed. That detail shapes how they treat it, and holding it back only slows things down.
No symptoms yet, but you think your pet got into cannabis? Call your vet or an out-of-hours emergency line. They will tell you whether to come in straight away or keep watch at home.
Cannabis poisoning in pets rarely enters the conversation when people debate drug policy. But for any household with animals, the stakes are real. What people bring home, leave in the garden, or even carry in on their clothing can end up harming their pets. Vets are seeing it happen every day.
(Source: WRD News)
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Millions of people with chronic knee pain have hoped that cannabis and opioids for pain might work better together. A new clinical trial published in Anesthesiology has challenged that idea. The research found no meaningful benefit from combining the two drugs. In some cases, the combination made things worse.
What the Study Found About Cannabis and Opioids for Pain
Researchers at Johns Hopkins University School of Medicine ran a rigorous, double-blind, randomised, placebo-controlled trial. They enrolled 21 adults with diagnosed knee osteoarthritis. Each participant attended four sessions, at least seven days apart. Every session involved a different drug combination: placebo only, the opioid hydromorphone (2mg) alone, the synthetic cannabinoid dronabinol (10mg) alone, or hydromorphone and dronabinol together.
The team measured a wide range of outcomes. These included sensitivity to pressure, heat and cold, self-reported pain scores, walking and stair-climbing ability, cognitive function, and side effects.
The results were straightforward. Neither the cannabinoid and opioid combination nor either drug alone produced meaningful pain relief. Hydromorphone raised the pressure pain threshold above dronabinol’s level. It also reduced mechanical pain sensitisation compared with placebo. But participants’ own knee pain ratings did not improve significantly under any condition.
Side Effects Increased Without Pain Relief
The combined condition raised real concerns about tolerability. Participants who took cannabis and opioids for pain together reported higher nausea, stronger feelings of being “high,” and slower working memory reaction times. None of this came with added pain relief.
“Our study suggests that isn’t the case and patients may experience more side effects when the drugs are combined,” said lead author Dr Katrina R. Hamilton of Ohio University and Johns Hopkins School of Medicine.
Growing numbers of people now combine cannabis with prescription painkillers. Many believe the approach is safer or more effective. This trial found no evidence to support that belief.
Why Preclinical Findings Did Not Translate to Humans
Animal studies long suggested that cannabinoids could boost the pain-relieving power of opioids. The theory was that patients might need lower opioid doses, which would reduce addiction risk. Interest in cannabis and opioids for pain grew steadily, driven by shifting legal landscapes and an ongoing opioid crisis. In the United States alone, opioid overdoses contributed to more than 80,000 deaths in a single recent year.
Yet human trials have consistently failed to replicate those animal findings. The Johns Hopkins team ran a similar trial earlier using a 4mg dose of hydromorphone. That study also found minimal added benefit from combining the two drugs. In that version, researchers recorded adverse events in 35.1% of all sessions. The highest rates occurred when participants took hydromorphone alone or alongside dronabinol. The current study dropped the dose to 2mg to test whether tolerability improved. Adverse events fell to 28.6% of sessions. Still, no significant differences emerged between the four drug conditions.
Cognition: A Mixed Picture for the Cannabinoid and Opioid Combination
Researchers flagged one unexpected finding worth watching. Hydromorphone alone impaired working memory accuracy more than every other condition. The cannabinoid and opioid combination slowed reaction times but did not hurt accuracy as much. The authors speculate that dronabinol might partially protect cognitive function when taken with an opioid. They stressed this remains highly preliminary and needs further study.
Researchers found no significant differences across conditions for fine motor movement, physical functioning, or measures of extramedical drug use risk.
Key Limitations to Consider
The trial was small. Only 21 participants completed all four sessions. The study used a single oral dose of synthetic THC rather than inhaled or full-spectrum cannabis. Most real-world users do not take cannabis this way. Inhaled cannabis reaches peak concentration in 3 to 10 minutes. The oral route used here takes one to two hours. Natural cannabis also contains more than 500 compounds. The synthetic version used in the study contains only pure THC, which may affect outcomes in ways not yet understood.
An editorial published alongside the study noted that participants had never used cannabis before. They also received a relatively high single dose. Both factors may limit how broadly these findings apply to everyday users.
What This Means for Using Cannabis and Opioids for Pain
The study adds to a body of controlled trial evidence. It consistently shows that the cannabinoid and opioid combination does not perform as hoped when tested in real patients with chronic pain. The preclinical promise simply has not carried through to clinical settings.
Patients and clinicians in areas where medical cannabis is legal should weigh this evidence carefully. Combining cannabis and opioids for pain in knee osteoarthritis currently lacks strong clinical justification. The side effect burden is real, and the benefits are not.
Future research should test different cannabis formulations, varied routes of administration, dose-ranging designs, and longer follow-up periods. Until that work arrives, the combination remains more risk than reward for most knee arthritis patients.
(Source: WRD News)
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