Guillermo, a 19-year-old Chicagoan, said the first time he got stoned “felt like I was a piece of butter melting on a stack of pancakes.” But the rapture faded quickly, and smoking weed soon became a joyless reflex akin to brushing his teeth in the morning, he said.

Potent marijuana frequently put him into hangoverlike “kush comas,” he said, and sapped his motivation and alertness so thoroughly that his mother threatened to put him into a mental hospital.

“I was just stoned all the time,” he said. “I was barely even there.”

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